FIGURE 5-6 Genetic transmission of sickle cell anemia
(A) Normal parent and parent who carries trait
AA
AAAAA
SASAS


1:2 (or 2:4) chance offspring will carry trait. 		(B) Two parents who carry trait
AS
AAAAS
SASSS


1:4 chance offspring will be normal.
1:4 chance offspring will will have sickle cell anemia.
1:2 (or 2:4) chance offspring will carry trait.
(C) Normal parent and parent with sickle anemia
AA
SASAS
SASAS


4:4 (100%) chance offspring will carry trait.
 (D) Parent with sickle cell anemia and parent who carries trait
AS
SASSS
SASSS


1:2 chance offspring will carry trait.
1:2 chance offspring will sickle cell anemia.
(E) Two parents with sickle cell anemia
SS
SSSSS
SSSSS


4:4 (100%) chance offspring will have sickle cell anemia
KeyAA= normal hemoglobin
AS= sickle cell trait
SS=sickle cell disease(anemia)


Note: The odds cited here are for each pregnancy