Early I R|L|I ER|L|IH I R|L|IH diagnosis JH|A + I|AX|G|N|O|S|AX|S D|IH|AX|G|N|O|S|AX|S JH|IH|AX|G|N|O|S|AX|S D|A + I|AX|G|N|U|S|AX|S JH|A + I|AX|G|N|U|S|AX|S D|IH|AX|G|N|U|S|AX|S JH|IH|AX|G|N|U|S|AX|S D|A + I|AX|G|N|O|SH|AX|SH JH|A + I|AX|G|N|O|SH|AX|SH D|IH|AX|G|N|O|SH|AX|SH JH|IH|AX|G|N|O|SH|AX|SH D|A + I|AX|G|N|U|SH|AX|SH JH|A + I|AX|G|N|U|SH|AX|SH D|IH|AX|G|N|U|SH|AX|SH JH|IH|AX|G|N|U|SH|AX|SH and AX|N|JH treatment T|R|IH|T|M|AX|N|T